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Critical Care Studies

Active Projects

Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)

Funding Agency: National Heart, Lung, and Blood Institute (NHLBI)

Denver Health is a part of the The Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL), a national network of 50+ hospitals that are funded to develop and conduct randomized controlled clinical trials to prevent or treat Acute Respiratory Distress Syndrome (ARDS). CLOVERS is a multicenter randomized, non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension.

Vitamin D to Improve Outcomes by Leveraging Early Treatment (VIOLET)

Funding Agency: National Heart, Lung, and Blood Institute (NHLBI)

Denver Health is a part of the The Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL), a national network of 50+ hospitals that are funded to develop and conduct randomized controlled clinical trials to prevent or treat Acute Respiratory Distress Syndrome (ARDS). VIOLET is a multicenter, randomized, double blind, placebo controlled trial that will assess the efficacy and safety of early administration of vitamin D3 (cholecalciferol) in reducing mortality and morbidity for vitamin D deficient patients at high risk for ARDS and mortality. 


Adherence to Clinical Practice Guidelines in the Emergency Department

Funding Agency: Agency for Healthcare Research and Quality (AHRQ) and University of Colorado Department of Emergency Medicine

The purpose of this project is to retrospectively examine physician aderence to emergency department specific clinical practice guidelines and estimate associations between patient, provider and environmental factors related to to (1) acute coronary syndrome, (2) acute ST-elevation myocardial infarction, (3) community acquired pneumonia, (4) acute ischemic stroke, and (5) severe sepsis or septic shock.  This multi-site project will provide the first comprehensive and comparitive study on emergency department quality of care and barriers to care.

A Two-Center Validation of Three Simplified Measures to Replace the Glasgow Coma Scale for Trauma Field Triage

This project is a secondary analysis of data that is prospectively collected and systematically maintained by trauma registries at Loma Linda University Medical Center and Denver Health Medical Center. The relative accuracy of the Simplified Motor Scale, GCS Motor <6 and GCS Motor <5 will be examined for the prediction of trauma outcomes.

Completed Projects 

The AVERT Sepsis Investigation (Assessment Of Variability In Early Resuscitation And Treatment For Sepsis)


 An Observational Study of Heart Rate Variability and Respiratory Rate Variability as Predictors of Injury Severity in Trauma Patients in the Pre-Hospital and ED Settings


Derivation and Validation of a Mortality Prediction Rule in the ED for SIRS Patients


Fluid Resuscitation in Pediatric DKA


BVM Handholding Techniques


Epidemiology of SIRS in the Emergency Department

Denver Health

Emergency Medicine Research